Worsening energy crises and the growing effects of climate change have spurred, among other things, concerted efforts to tackle global problems through what the United Nations calls Sustainable Development Goals (SDGs). These are in turn argued to be best achieved via the adoption of environmental, social, and corporate governance (ESG) as the vehicle for guiding our efforts. However, though these things are often presented as the solution to global issues, they are increasingly being used as a means to centralize power (...) and exacerbate growing authoritarian trends. This article aims to demonstrate how the narratives surrounding ESG mask this reality, taking as a solution one of the foundational causes of global wealth and power disparity. (shrink)

In this study, screening positive for probable depression was common among undergraduate students at the University of the Witwatersrand, Johannesburg, South Africa and associated with sociodemographic and selected behavioral factors. These findings call for strengthening the awareness and use of counselling services among undergraduate students.

Four studies explore the role of perceptual fluency in attenuating bullshit receptivity, or the tendency for individuals to rate otherwise meaningless statements as “profound”. Across four studies, we presented participants with a sample of pseudoprofound bullshit statements in either a fluent or disfluent font and found that overall, disfluency attenuated bullshit receptivity while also finding little evidence that this effect was moderated by cognitive thinking style. In all studies, we measured participants’ cognitive reflection, need for cognition, faith in intuition, and (...) superstitious beliefs. Superstition strongly predicted bullshit receptivity regardless of fluency. Inconclusive results were found for the remaining scales. Potential links for the role of perceptual disfluency in promoting analytic thinking are discussed. (shrink)

The rapid expansion of Big Tech companies into various societal domains (e.g., health, education, and agriculture) over the past decade has led to increasing concerns among governments, regulators, scholars, and civil society. While existing theoretical frameworks—often revolving around privacy and data protection, or market and platform power—have shed light on important aspects of Big Tech expansionism, there are other risks that these frameworks cannot fully capture. In response, this editorial proposes an alternative theoretical framework based on the notion of sphere (...) transgressions, which draws on political philosopher Michael Walzer's theory of justice. The editorial not only introduces the sphere transgressions framework, but it also highlights its potential to generate novel research questions. Furthermore, this editorial introduces eight articles and one commentary from a group of interdisciplinary scholars that critically examine Big Tech expansionism by reflecting on this expansionism from the perspective of different societal spheres or by engaging with the sphere transgressions framework itself. (shrink)

Significant associations have been found between specific human leukocyte antigen (HLA) alleles and organ transplant rejection, autoimmune disease development, and the response to infection. Traditional searches for disease associations have conventionally measured risk associated with the presence of individual HLA alleles. However, given the high level of HLA polymorphism, the pattern of amino acid variability, and the fact that most of the HLA variation occurs at functionally important sites, it may be that a combination of variable amino acid sites shared (...) by several alleles (shared epitopes) are better descriptors of the actual causative genetic variants. Here we describe a novel approach to genetic association analysis in which genes/proteins are broken down into smaller sequence features and then variant types defined for each feature, allowing for independent analysis of disease association with each sequence feature variant type. We have used this approach to analyze a cohort of systemic sclerosis patients and show that a sequence feature composed of specific amino acid residues in peptide binding pockets 4 and 7 of HLA-DRB1 explains much of the molecular determinant of risk for systemic sclerosis. (shrink)

The potential for vaccines to prevent the spread of infectious diseases is crucial for vaccination policy and ethics. In this paper, I discuss recent evidence that the current COVID-19 vaccines have only a modest and short-lived effect on reducing SARS-CoV-2 transmission and argue that this has at least four important ethical implications. First, getting vaccinated against COVID-19 should be seen primarily as a self-protective choice for individuals. Second, moral condemnation of unvaccinated people for causing direct harm to others is unjustified. (...) Third, the case for a harm-based moral obligation to get vaccinated against COVID-19 is weak. Finally, and perhaps most significantly, coercive COVID-19 vaccination policies (e.g., measures that exclude unvaccinated people from society) cannot be directly justified by the harm principle. (shrink)

This review article provides a brief descriptive overview of past efforts to use self-referential argumentation, distinguishing pragmatical from metalogical self-referential approaches. The reviewer claims that the pragmatical self-referential argument proposed in this book is itself metalogically self-referentially inconsistent, and directs the reader to other relevant published works by the reviewer.

Onychectomy involves the surgical amputation of a cat's claws. Tendonectomy entails surgically cutting tendons to prevent the extension and full use of a cat's claws. Both surgeries practically declaw cats and are not only painful but also associated with high complication rates. While feline declawing surgeries have been banned in various places around the world, they are still elective in many countries and U.S. states. This article provides an ethical analysis of declawing cats. It discusses the harms posed by feline (...) declawing surgeries, like pain and complications, which are not offset by any benefits to cats. Drawing on Martha Nussbaum's capabilities approach, it also offers an additional and broader ethical argument against declawing, namely that removing cats' claws is unjust because it thwarts important capabilities for feline flourishing (e.g., play, bodily integrity, control over one's environment). It concludes that declawing cats for non-medical purposes is unethical and must be opposed. (shrink)

The repugnant conclusion poses a conundrum in population ethics that has evaded satisfactory solution for four decades. In this article, I show that the repugnant conclusion can be avoided without sacrificing any moral intuitions. The resulting framework satisfies Parfit's requirements for `theory X'. This is achieved using non-Archimedean orders, which admit the possibility of pairs of goods for which no amount of one is better than a single unit of the other. I show that with minimal assumptions, not only are (...) such goods sensible, they are compulsory. I show that utilitarianism and expected utility theory in their canonical forms are not in general suitable in this setting, and using these tools naively can lead to ethical errors that are arbitrarily serious. Multi-dimensional lexicographic expected utility representations may be required. I use fuzzy sets to show that there needn't be a clear boundary separating goods that are not Archimedean equivalent. This may be unavoidable due to intrinsic physical limits on the ability to discriminate between different goods arising from e.g. quantum mechanics. Limited discriminatory power causes preferences to be non-transitive, which can resolve problems related to so-called `fanaticism' and `recklessness' wherein `rational' decision-makers counterintuitively prefer arbitrary long shot bets to a guaranteed lesser outcome. (shrink)

An Address delivered to the Seattle G. K. Chesterton Society at the University of Washington Newman Center, May 2, 2013.

A book review of _Free Choice: A Self-referential Argument_ by J. M. Boyle, Jr., G. Grisez, and O. Tollefsen. The review concerns the pragmatical self-referential argument employed in the book, and points to the fact that the argument is itself self-referentially inconsistent, but on the level of metalogical self-reference.

A new book by Batya Friedman and David G. Hendry, Value Sensitive Design: Shaping Technology with Moral Imagination, is reviewed. Value Sensitive Design is a project into the ethical and design issues that emerge during the engineering programs of new technologies. This book is intended to build on the over two decades of value sensitive design research, however with a greater emphasis on the developments of the theoretical underpinnings of the approach as well as initial steps that designers can employ (...) to put the method into practice. (shrink)

Arguably the biggest challenge in analyzing English tense is to account for the double access interpretation, which arises when a present tensed verb is embedded under a past attitude—e.g., "John said that Mary is pregnant". Present-under-past does not always result in a felicitous utterance, however—cf. "John believed that Mary is pregnant". While such oddity has been noted, the contrast has never been explained. In fact, English grammars and manuals generally prohibit present-under-past. Work on double access, on the other hand, has (...) either disregarded the oddity (e.g., Abusch 1997: 39) or treated it as a reflex of a particular dialect (e.g., Kratzer 1998: 14). The goal of the paper is to argue—based on a corpus study—that a present-under-past sentence is grammatical, but modulated by two, interacting pragmatic phenomena: cessation and parentheticality. (shrink)

This article is part of a For-Discussion-Section of Methods of Information in Medicine about the paper "Biomedical Informatics: We Are What We Publish", written by Peter L. Elkin, Steven H. Brown, and Graham Wright. It is introduced by an editorial. This article contains the combined commentaries invited to independently comment on the Elkin et al. paper. In subsequent issues the discussion can continue through letters to the editor.

Εκτενής Βιβλιοκριτική της έκδοσης: Plotinus Ennead VI.4 and VI.5: On the Presence of Being, One and the Same, Everywhere as a Whole («The Enneads of Plotinus with Philosophical Commentaries»). Εισαγωγή, αγγλική μετάφραση, υπόμνημα Eyjolfur Kjalar Emilsson & Steven Keith Strange. Las Vegas/Zurich/Athens: Parmenides Publishing 2015, 305 σ., 36 €.

Contemporary discussions about operational definition often hark back to Stanley Smith Stevens’ classic papers on psychological operationism (1935ab). Still, he was far from the only psychologist to call for conceptual hygiene. Some of Stevens’ direct colleagues at Harvard---most notably B. F. Skinner and E. G. Boring---were also actively applying Bridgman’s conceptual strictures to the study of mind and behavior. In this paper, I shed new light on the history of operationism by reconstructing the Harvard debates about operational definition in the (...) years before Stevens published his seminal articles. Building on a large set of archival evidence from the Harvard University Archives, I argue that we can get a more complete understanding of Stevens’ contributions if we better grasp the operationisms of his former teachers and direct colleagues at Harvard’s Department of Philosophy and Psychology. (shrink)

I start with some famous comments by the philosopher (psychologist) Ludwig Wittgenstein because Pinker shares with most people (due to the default settings of our evolved innate psychology) certain prejudices about the functioning of the mind and because Wittgenstein offers unique and profound insights into the workings of language, thought and reality (which he viewed as more or less coextensive) not found anywhere else. The last quote is the only reference Pinker makes to Wittgenstein in this volume, which is most (...) unfortunate considering that he was one of the most brilliant and original analysts of language. -/- In the last chapter, using the famous metaphor of Plato’s cave, he beautifully summarizes the book with an overview of how the mind (language, thought, intentional psychology) –a product of blind selfishness, moderated only slightly by automated altruism for close relatives carrying copies of our genes--works automatically, but tries to end on an upbeat note by giving us hope that we can nevertheless employ its vast capabilities to cooperate and make the world a decent place to live. -/- Pinker is certainly aware of but says little about the fact that far more about our psychology is left out than included. Among windows into human nature that are left out or given minimal attention are math and geometry, music and sounds, images, events and causality, ontology (classes of things), dispositions (believing, thinking, judging, intending etc) and the rest of intentional psychology of action, neurotransmitters and entheogens, spiritual states (e.g, satori and enlightenment, brain stimulation and recording, brain damage and behavioral deficits and disorders, games and sports, decision theory (incl. game theory and behavioral economics), animal behavior (very little language but a billion years of shared genetics). Many books have been written about each of these areas of intentional psychology. The data in this book are descriptions, not explanations that show why our brains do it this way or how it is done. How do we know to use the sentences in their various way (i.e., know all their meanings)? This is evolutionary psychology that operates at a more basic level –the level where Wittgenstein is most active. And there is scant attention to context. -/- Nevertheless this is a classic work and with these cautions is still well worth reading. -/- Those wishing a comprehensive up to date framework for human behavior from the modern two systems view may consult my book ‘The Logical Structure of Philosophy, Psychology, Mind and Language in Ludwig Wittgenstein and John Searle’ 2nd ed (2019). Those interested in more of my writings may see ‘Talking Monkeys--Philosophy, Psychology, Science, Religion and Politics on a Doomed Planet--Articles and Reviews 2006-2019 3rd ed (2019), The Logical Structure of Human Behavior (2019), and Suicidal Utopian Delusions in the 21st Century 4th ed (2019). (shrink)

● Any given placement (e.g. Sun in Taurus; Mars in Capricorn; Mercury in the third house) is necessarily common to tens of thousands of people. Saturn in the ninth house, for example, will not behave the same or produce the same effects in the twenty or one hundred charts in which we find it there. In each case Saturn will behave in accordance with the rest of the astrographic/chart composition (as if we stayed in the same hotel in different epochs (...) or different people contracted the same disease; our stay will be different each time, according to the epoch, and each person’s symptoms will too, be different, according to their individual biochemistry; not to mention that each chart or astrography, like each genetic code or sequence, is unrepeatable). Certainly, “no planet can produce, on its own, what only the combined or concerted action of all can” (BUSTAMANTE, 2023, SPICA magazine, pp. 93-111). Hence the synergistic nature of the interpretative exercise (i.e., the whole is greater than all its parts). The fundamental component of the mathematical expression of the interpretive exercise is: astrological triangulation, the functional denomination for what we know as synthesis (WEISS, 1946; LEO, 1983, HAND, 1981). In order to demonstrate its usefulness, as well as the convenience of its mathematical expression, we have chosen two individuals (JEFFREY DAHMER, STEVEN SPIELBERG) whose astrographies do not—according to the community—explain their lives. The rest of the astrographies correspond to those of serial killers JOHN WAYNE GACY, DAVID CARPENTER, and TED BUNDY. ● We explain, by means of algebraic notations, the synthesis and the functional values that make up the synthesis. ● We take the Moon and Neptune as relevant bodies for the purpose of diagnosing or studying endocrine or neurohormonal issues, and Mars, Pluto, and Saturn as relevant planets for the purpose of inferring violence or sinister behaviour, upon the case, and quadratures or oppositions—and conjunctions—between Venus and the Moon, the Moon and Neptune, and the Sun or Venus and Neptune or Uranus as indicators of neurohormonal disorders and/or sexual deviance (APA definition) . ● We consider quadratures (90º) or oppositions (180º)—and conjunctions—between Mercury or the Moon and Saturn, or between Mars or the Moon and Saturn, Uranus, Neptune, and/or Pluto as powerful indications of violence or mental disorders, upon the case. ● We have also regarded Sagittarius as a sign as expansive and abundant as its ruler, Jupiter, according to the best of its characterisations (or as an exceptionally swift and wild sign, according to other characterisations), and the fifth region of a natal chart as one closely related to fortune in a broad sense (material and immaterial). ● Because we advocate the idea that orbs should be predicated of the planet (size, speed), not the aspect itself, the gas giants (Jupiter, Saturn, Uranus, and Neptune) and the Sun have been granted up to 10º of orb (or 12º, in the case of broad influence ). We understand aspectual relationships as angular relationships held between two or more celestial bodies placed in signs with at least one property in common (according to our molecular theory of the ecliptic, compatible with the optical theory of the aspects from the Hellenistic tradition). (shrink)

Though the concepts of diversity and inclusion are still widely used in the contexts of management, policy-making, and academic research, the notion of superdiversity is becoming increasingly popular. First articulated by social anthropologist Steven Vertovec (see Vertovec, 2006; 2007; 2012), superdiversity has been described as a concept and theoretical tool that enables us to study our ever-evolving, globalising social reality in great detail by taking the enormous amount of diversity that exists within different groups in societies around the world (...) into account as well, in addition to differences between different groups. Superdiversity is mainly linked to the growing ethnic and cultural complexity of Western European societies, and is therefore often associated with the rise of so-called majority-minority- cities, such as Amsterdam, Brussels, and London, to name a few – all cities in which ethnic minority groups are about to replace (or have already replaced) the ethnic majority group (see, e.g., Crul, Schneider, & Lelie, 2013; Crul, 2016; Geldof, 2015). (shrink)

With An Answer to the Question: What Is Enlightenment? (1784) and What Does It Mean to Orient Oneself in Thinking? (1786), Kant presents the concept of public use of reason and defines its requirements, scope, and function. In outline, the public use of reason consists in sharing one’s thoughts with “the entire public of the world of readers” (8:37). As for its requirements, to the extent that someone communicates in their own person, i.e. not in the exercise of their function (...) as a public official, and bases their reasoning on universalizable grounds, their use of reason qualifies as public and shall be free from state censorship. Therefore, Kant’s concept of public use reason aims to establish a public debate that is free and includes in its scope, both as subjects and recipients, potentially all adult men. The ultimate function of the public use of reason is to foster moral progress and, with it, the reform of the political community according to the republican ideal. However, it is commonly held that Kant, with his 1798 essay The Conflict of the Faculties, deprives his notion of public use of reason of its progressive core and adjusts it to the absolutist conception of speech and civil service. Characterizations of state officials as “not free to make public use of their learning” (7:18) and “bound to uphold whatever […] the crown sanctions for them to expound publicly” (7:8), as well as the depiction of laypeople as “incompetent” (7:18) and “resigned to understanding nothing about [the sciences]” (7:34), have led influential interpreters to read Kant as redefining his notion of public use of reason by restricting its subjects to university professors and its recipients to government members (e.g. John Christian Laursen 1986, rpt. 1992 and 1996; Kevin Davis 1992; Steven Lestition 1993; Jay Franzel 2013). On my reading, with The Conflict of the Faculties, Kant does indeed redefine the concept of public use of reason making concessions to the absolutist notion of speech and civil service. However, a close reading of the text reveals that the public use of reason ends up being reaffirmed in its progressive core and extended in its scope. To substantiate my interpretation, I will systematically analyse and classify each of the 68 occurrences of the adjective ‘public’ in The Conflict of the Faculties and show how Kant employs the absolutist vocabulary to convey the progressive project of his previous writings. Accordingly, I argue that Kant holds on to the free public use of reason as a means to reform politics according to the republican ideal and that the employment of the absolutist vocabulary is motivated by a pragmatic attitude and a provocative stance. (shrink)

_La Peste_, originally published in 1947 by the Nobel Prize-winning writer Albert Camus, chronicles the progression of deadly bubonic plague as it spreads through the quarantined Algerian city of Oran. While most discussions of fictional examples within aesthetics are either historical or hypothetical, Camus offers an example of "pestilence fiction." Camus chose fiction to convey facts--about plagues in the past, his own bout with tuberculosis at age seventeen, living under quarantine away from home for several years, and forced separation from (...) his wife who remained in Algiers while he was abroad in Nazi-occupied France. His own lived experiences undergird an imaginative account of shared human realities with which we can identify: vulnerability to the disease, isolation, fear, and finally humanitarianism. _The Plague_ teaches us to neither covet nor expect what we so casually took for granted. This collection of original essays on philosophical themes in _The Plague_ is of special relevance during and in the aftermath of Covid-19 but also provides reflections that will be of lasting value to those interested in this classic work of literature. The novel explores questions of enduring importance. Do we collectively meet the threshold of ethical behavior posed by Camus who wrote, "What's true of all the evils in the world is true of plague as well. It helps men to rise above themselves"? Or does the absurd undermine the compassionate? Do "heroes" dutifully fight a plague with "common decency," or does human nature resign itself to the normalization of uncontrollable suffering and death? There are myriad ways to approach the novel and this volume encourages readers to ponder human dilemmas in fictional Oran informed by our current pandemic. Series editor forward by Richard Eldridge. List of Contributors includes Steven G. Kellman, Jane E. Schultz, Andrew Edgar, Kathleen Higgins, Edward B. Weiser, Cynthia A. Freeland, and Margaret E. Gray; see "Introduction" by Peg Brand Weiser below. (shrink)

Though this volume is a bit dated, there are few recent popular books dealing specifically with the psychology of murder and it’s a quick overview available for a few dollars, so still well worth the effort. It makes no attempt to be comprehensive and is somewhat superficial in places, with the reader expected to fill in the blanks from his many other books and the vast literature on violence. For an update see e.g., Buss, The Handbook of Evolutionary Psychology 2nd (...) ed. V1 (2016) p 265, 266, 270–282, 388–389, 545–546, 547, 566 and Buss, Evolutionary Psychology 5th ed. (2015) p 26, 96–97,223, 293-4, 300, 309–312, 410 and Shackelford and Hansen, The Evolution of Violence (2014) He has been among the top evolutionary psychologists for several decades and covers a wide range of behavior in his works, but here he concentrates almost entirely on the psychological mechanisms that cause individual people to murder and their possible evolutionary function in the EEA (Environment of Evolutionary Adaptation—i.e., the plains of Africa during the last million years or so). -/- Buss starts by noting that as with other behaviors, ‘alternative’ explanations such as psychopathology, jealousy, social environment, group pressures, drugs and alcohol etc. do not really explain, since the question still remains as to why these produce homicidal impulses, i.e., they are the proximate causes and not the ultimate evolutionary (genetic) ones. As always, it inevitably boils down to inclusive fitness (kin selection), and so to the struggle for access to mates and resources, which is the ultimate explanation for all behavior in all organisms. Sociological data (and common sense) make it clear that younger poorer males are the most likely to kill. He presents his own and others homicide data from industrialized nations, and tribal cultures, conspecific killing in animals, archeology, FBI data and his own research into normal people's homicidal fantasies. Much archeological evidence continues to accumulate of murders, including that of whole groups, or of groups minus young females, in prehistoric times. -/- After surveying Buss’s comments, I present a very brief summary of intentional psychology (the logical structure of rationality), which is covered extensively in my many other articles and books. -/- Those with a lot of time who want a detailed history of homicidal violence from an evolutionary perspective may consult Steven Pinker’s ‘The Better Angels of Our Nature Why Violence Has Declined’(2012), and my review of it easily available on the net and in two of my recent ebooks. Briefly, Pinker notes that murder has decreased steadily and dramatically by a factor of about 30 since our days as foragers. So, even though guns now make it extremely easy for anyone to kill, homicide is much less common. Pinker thinks this is due to various social mechanisms that bring out our ‘better angels’, but I think it’s due mainly to the temporary abundance of resources from the merciless rape of our planet, coupled with increased police presence, with communication and surveillance and legal systems that make it far more likely to be punished. This becomes clear every time there is even a brief and local absence of the police. -/- Those wishing a comprehensive up to date framework for human behavior from the modern two systems of thought viewpoint may consult my e-book ‘The Logical Structure of Philosophy, Psychology, Mind and Language in Wittgenstein and Searle 367p (2016). Those interested in more of my writings on psychology may see Suicidal Utopian Delusions in the 21st Century--Philosophy, Human Nature and the Collapse of Civilization 392p (2017). For all my writings in their most recent versions, please consult my e-book Philosophy, Human Nature and the Collapse of Civilization - Articles and Reviews 2006-2017 3rd Ed. 686p (2017). -/- All of my papers and books have now been published in revised versions both in ebooks and in printed books. -/- Talking Monkeys: Philosophy, Psychology, Science, Religion and Politics on a Doomed Planet - Articles and Reviews 2006-2017 (2017) https://www.amazon.com/dp/B071HVC7YP. -/- The Logical Structure of Philosophy, Psychology, Mind and Language in Ludwig Wittgenstein and John Searle--Articles and Reviews 2006-2016 (2017) https://www.amazon.com/dp/B071P1RP1B. -/- Suicidal Utopian Delusions in the 21st century: Philosophy, Human Nature and the Collapse of Civilization - Articles and Reviews 2006-2017 (2017) https://www.amazon.com/dp/B0711R5LGX -/- . (shrink)

NUTRIÇÃO SOBRE A AZOOSPERMIA EM BOVINOS -/- -/- E. I. C. da Silva Departamento de Agropecuária – IFPE Campus Belo Jardim Departamento de Zootecnia – UFRPE sede -/- AZOOSPERMIA EM BOVINOS -/- INTRODUÇÃO -/- A falta completa de esperma no ejaculado pode ser devido a uma falha no processo de espermatogênese ou relacionada a causas no transporte do esperma. Com relação ao transporte, o esperma pode ser impedido de ser ejaculado mediante bloqueios ou oclusões no sistema do ducto extragonadal, ou (...) por causa de uma disfunção ejaculatória. Nos cães, por exemplo, a possibilidade de oclusão ser a causa pode ser determinada por medições de fosfatase alcalina (ALP) no plasma seminal, já que a ALP se origina do epidídimo e seminífero epitélio tubular. Se a concentração de ALP no fluido seminal for superior a 5000 UI/l, a amostra ejaculada contém fluido desses tecidos e a oclusão pode ser descartada. -/- As causas testiculares da azoospermia incluem a falha da espermatogênese, que pode ser causada por uma série de fatores; estes incluem fatores hormonais, imunológicos, congênitos, tóxicos, patogênicos, traumáticos e nutricionais. Aqui, as supressões na região do AZF (que contém sub-regiões AZFa, AZFb e AZFc) no cromossoma Y desempenham um papel importante, representando 10-15% dos casos de azoo- e oligospermia. Na região AFZc, o gene DAZ, que é suprimido na azoospermia, é considerado importante no controle espermatogênico, uma vez que a sua eliminação é frequentemente detectada em homens e/ou animais inférteis. -/- A perda total da capacidade de formação de espermatozoides pelo epitélio testicular e, portanto, a ausência de espermatozoides viáveis ou não no volume ejaculado pelo animal é denominado como azoospermia (VARNER et al., 2000), um macho nessas condições deve ser imediatamente retirado dos processos produtivos e não é, de forma alguma, viável para fins reprodutivos. A origem da causa pode ter caráter nutricional, ou outras, sendo multifatoriais; em processos crônicos severos pode-se chegar à azoospermia reversível, que é diagnosticada e corrigida de forma oportuna. Entre os principais fatores de caráter nutricional temos: -/- 18.1 Nitratos (NO3-) e nitritos (NO2-) -/- Quando os ruminantes consomem uma alimentação com elevadas concentrações de nitratos (presente principalmente nas forrageiras) parte do nitrato não pode ser imediatamente convertido em nitrito e, por fim, em amoníaco (todas essas transformações acontecem no rúmen mediante a flora microbiana); isso faz com que nitrato e nitrito se acumulem no rúmen. A adição do nitrato no rúmen intensifica o problema. O envenenamento por nitrato ocorre quando o nível de nitrito presente no rúmen excede a capacidade do microbiota para convertê-lo em amoníaco. Quando isto acontece, o nitrato e o nitrito são absorvidos através da parede do rúmen e entram na circulação sanguínea. É o nitrito que causa a toxicidade. -/- Estudou-se o equilíbrio ácido-básico e sua relação com a reprodução e produção, postulando a hipótese de que esse equilíbrio afeta os mecanismos endócrinos e metabólicos, além dos reprodutivos. -/- 18.2 Relação energia:proteína -/- Quando a alimentação apresenta deficiências de energia aumenta-se a degradação das gorduras (provenientes do tecido adiposo), acompanhada pela redução da liberação de insulina (hipoinsulinemia) afetando-se a lipogênese, mobilizando-se mais gordura corporal do que se sintetiza. -/- Situações como a acidose ruminal (excesso de grão e deficiência em fibras) ou alcalose ruminal (excesso de ureia com baixa energia digerível) resultam em perturbações sobre a fertilidade; além disso, deficiências energéticas graves que levam à cetose causam estresse com a liberação de catecolaminas, ACTH e TSH que afetam a secreção de GnRH, afetando por fim, a espermiogênese. -/- -/- Uma diminuição de energia na alimentação gera hipoglicemia que, ao mesmo tempo, produz hipoinsulinemia incrementando assim a lipólise em tecidos, gerando como produtos as cetonas. -/- A hipoinsulinemia juntamente com a cetonemia e a geração de beta-endorfinas, por problemas na alimentação, reduzem notavelmente a síntese de GnRH. A GnRH reduz a liberação do LH e FSH. A diminuição da liberação do LH provoca azoospermia hipogonadotrópica com efeitos de estimulação hormonal anormais segundo a avaliação endócrina, bem como a obstrução testicular inexplicada. -/- Se houver um aumento significativo na liberação de FSH, a azoospermia hipogonadotrópica é refletida em diagnóstico como disfunção testicular. -/- 18.3 Minerais (Selênio Se) -/- Quando os níveis de Se na dieta são deficientes, ocorrem falhas na formação e maturação espermática. O Se mostra uma grande influência na fertilidade do macho afetando a qualidade do sêmen, o plasma seminal contém elevadas quantidades de GSH-Px, cuja função é proteger a membrana do espermatozoide do ataque peroxidativo; além disso, na cauda do gameta masculino há um selenopeptídeo que faz com que, em uma deficiência de Se, produza-se uma fratura no meio da cauda do espermatozoide. -/- O esperma dos animais com deficiência de Se apresentam pobre motilidade com características de desenvolvimento anormal na cauda do esperma. Demonstrou-se que a deficiência de Se, não somente precipita o problema em reprodutores, mas que o esperma deformado, foi menos efetivo na subsequente fertilização do ovócito ovulado (HAWKES et al., 2001), ou seja, animais que possuem deficiência desse mineral podem ter esperma inapropriado para a destinação de inseminação artificial ou mesmo a monta natural, uma vez que a taxa de concepção estará bastante baixa. -/- REFERÊNCIAS BIBLIOGRÁFICAS -/- BARRENHO, Gonçalo José Pinheiro. Nutrição e fertilidade em bovinos de leite. 2016. Dissertação de Mestrado. Universidade de Évora. -/- BINDARI, Yugal Raj et al. Effects of nutrition on reproduction-A review. Adv. Appl. Sci. Res, v. 4, n. 1, p. 421-429, 2013. -/- BOLAND, M. P. Efectos nutricionales en la reproducción del ganado. XXXI Jornadas Uruguayas de Buiatría, 2003. -/- CHENOWETH, Peter J.; LORTON, Steven (Ed.). Animal Andrology: Theories and Applications. Boston: Cabi, 2014. -/- -/- DEHNING, R. Interrelaciones entre nutrición y fertilidad. In: Curso Manejo de la Fertilidad Bovina18-23 May 1987Medellín (Colombia). CICADEP, Bogotá (Colombia) Universidad de La Salle, Medellín (Colombia) Instituto Colombiano Agropecurio, Bogotá (Colombia) Sociedad Alemana de Cooperación Técnica-GTZ (Alemania), 1987. -/- DE LUCA, Leonardo J. Nutrición y fertilidad en el ganado lechero. XXXVI Jornadas Uruguayas de Buiatría, 2008. -/- DIAS, Juliano Cesar et al. Alguns aspectos da interação nutrição-reprodução em bovinos: energia, proteína, minerais e vitaminas. PUBVET, v. 4, p. Art. 738-743, 2010. -/- FRAZER, Grant S. Bovine theriogenology. Veterinary Clinics: Food Animal Practice, v. 21, n. 2, p. xiii-xiv, 2005. -/- FRENEAU, G. E.; GUIMARÃES, J. D. Curso Teórico-Prático de Andrologia Bovina. Goiânia: Laboratório de andrologia e Tecnologia de Sêmen da Escola de Veterinária da Universidade Federal de Goiás, 2000. -/- GORDON, Ian. Controlled reproduction in farm animals series. Nova Iorque: CAB International, 1996. -/- HAWKES, WAYNE CHRIS; TUREK, PAUL J. Effects of dietary selenium on sperm motility in healthy men. Journal of Andrology, v. 22, n. 5, p. 764-772, 2001. -/- MAAS, John. Relationship between nutrition and reproduction in beef cattle. The Veterinary Clinics of North America. Food Animal Practice, v. 3, n. 3, p. 633-646, 1987. -/- SHORT, Robert E.; ADAMS, D. C. Nutritional and hormonal interrelationships in beef cattle reproduction. Canadian Journal of Animal Science, v. 68, n. 1, p. 29-39, 1988. -/- THATCHER, W. W. et al. Strategies for improving fertility in the modern dairy cow. Theriogenology, v. 65, n. 1, p. 30-44, 2006. -/- TEIXEIRA, J. C.; TEIXEIRA, LFAC. Alimentação de bovinos leiteiros. FAEPE, Lavras, 1997. -/- VARNER, D. D. et al. Techniques for evaluating selected reproductive disorders of stallions. Animal reproduction science, v. 60, p. 493-509, 2000. (shrink)

Much of the recent philosophical discussion about free will has been focused on whether compatibilists can adequately defend how a determined agent could exercise the type of free will that would enable the agent to be morally responsible in what has been called the basic desert sense :5–24, 1994; Fischer in Four views on free will, Wiley, Hoboken, 2007; Vargas in Four views on free will, Wiley, Hoboken, 2007; Vargas in Philos Stud, 144:45–62, 2009). While we agree with Derk Pereboom (...) and others that the compatibilist’s burden should be properly understood as providing a compelling account of how a determined agent could be morally responsible in the basic desert sense, the exact nature of this burden has been rendered somewhat unclear by the fact that there has been no definitive account given as to what the basic desert sense of moral responsibility amounts to. In Sect. 1 we set out to clarify the compatibilist’s burden by presenting our account of basic desert moral responsibility—which we call retributivist desert moral responsibility for purposes of clarity—and explain why it is of central philosophical and practical importance to the free will debate. In Sect. 2 we employ a thought experiment to illustrate the kind of difficulty that compatibilists of any stripe are likely to encounter in attempting to explain how determined agents can exercise the kind of free will needed for retributivist desert moral responsibility. (shrink)

Different people reason differently, which means that sometimes they reach different conclusions from the same evidence. We maintain that this is not only natural, but rational. In this essay we explore the epistemology of that state of affairs. First we will canvass arguments for and against the claim that rational methods of reasoning must always reach the same conclusions from the same evidence. Then we will consider whether the acknowledgment that people have divergent rational reasoning methods should undermine one’s confidence (...) in one’s own reasoning. Finally we will explore how agents who employ distinct yet equally rational methods of reasoning should respond to interactions with the products of each others’ reasoning. We find that the epistemology of multiple reasoning methods has been misunderstood by a number of authors writing on epistemic permissiveness and peer disagreement. (shrink)

Learning programming is thought to be troublesome. One doable reason why students don’t do well in programming is expounded to the very fact that traditional way of learning within the lecture hall adds more stress on students in understanding the Material rather than applying the Material to a true application. For a few students, this teaching model might not catch their interest. As a result, they'll not offer their best effort to grasp the Material given. Seeing however the information is (...) applied to real issues will increase student interest in learning. As a consequence, this may increase their effort to be taught. In the current paper, we try to help students learn C# programming language using Intelligent Tutoring System. This ITS was developed using ITSB authoring tool to be able to help the student learn programming efficiently and make the learning procedure very pleasing. A knowledge base using ITSB authoring tool style was used to represent the student's work and to give customized feedback and support to students. (shrink)

Psychopaths routinely disregard social norms by engaging in selfish, antisocial, often violent behavior. Commonly characterized as mentally disordered, recent evidence suggests that psychopaths are executing a well-functioning, if unscrupulous strategy that historically increased reproductive success at the expense of others. Natural selection ought to have favored strategies that spared close kin from harm, however, because actions affecting the fitness of genetic relatives contribute to an individual’s inclusive fitness. Conversely, there is evidence that mental disorders can disrupt psychological mechanisms designed to (...) protect relatives. Thus, mental disorder and adaptation accounts of psychopathy generate opposing hypotheses: psychopathy should be associated with an increase in the victimization of kin in the former account but not in the latter. Contrary to the mental disorder hypothesis, we show here in a sample of 289 violent offenders that variation in psychopathy predicts a decrease in the genetic relatedness of victims to offenders; that is, psychopathy predicts an increased likelihood of harming non-relatives. Because nepotistic inhibition in violence may be caused by dispersal or kin discrimination, we examined the effects of psychopathy on (1) the dispersal of offenders and their kin and (2) sexual assault frequency (as a window on kin discrimination). Although psychopathy was negatively associated with coresidence with kin and positively associated with the commission of sexual assault, it remained negatively associated with the genetic relatedness of victims to offenders after removing cases of offenders who had coresided with kin and cases of sexual assault from the analyses. These results stand in contrast to models positing psychopathy as a pathology, and provide support for the hypothesis that psychopathy reflects an evolutionary strategy largely favoring the exploitation of non-relatives. (shrink)

This chapter takes the form of a discussion between the editors of this volume and Steven Lukes, one the most eminent critics of methodological individualism. The focus is on Lukes’ interpretation of methodological individualism in terms of linguistic exclusivism (i.e., naive reductionism), the multiple-realization problem, Boudon’s and Elster’s micro-foundationalist approach, ontological individualism, and the rationality of human action.

The purpose of this paper is to review and critique Wessel Reijers and Bert Gordijn’s paper Moving from value sensitive design to virtuous practice design. In doing so, it draws on recent literature on developing value sensitive design (VSD) to show how the authors’ virtuous practice design (VPD), at minimum, is not mutually exclusive to VSD. This paper argues that virtuous practice is not exclusive to the basic methodological underpinnings of VSD. This can therefore strengthen, rather than exclude the VSD (...) approach. Likewise, this paper presents not only a critique of what was offered as a “potentially fruitful alternative to VSD” but further clarifies and contributes to the VSD scholarship in extending its potential methodological practices and scope. It is concluded that VPD does not appear to offer any original contribution that more recent instantiations of VSD have not already proposed and implemented. (shrink)

Jeff Paris proves a generalized Dutch Book theorem. If a belief state is not a generalized probability then one faces ‘sure loss’ books of bets. In Williams I showed that Joyce’s accuracy-domination theorem applies to the same set of generalized probabilities. What is the relationship between these two results? This note shows that both results are easy corollaries of the core result that Paris appeals to in proving his dutch book theorem. We see that every point of accuracy-domination defines a (...) dutch book, but we only have a partial converse. (shrink)

In the literature on supervaluationism, a central source of concern has been the acceptability, or otherwise, of its alleged logical revisionism. I attack the presupposition of this debate: arguing that when properly construed, there is no sense in which supervaluational consequence is revisionary. I provide new considerations supporting the claim that the supervaluational consequence should be characterized in a ‘global’ way. But pace Williamson (1994) and Keefe (2000), I argue that supervaluationism does not give rise to counterexamples to familiar inference-patterns (...) such as reductio and conditional proof. (shrink)

A term expresses a thick concept if it expresses a specific evaluative concept that is also substantially descriptive. It is a matter of debate how this rough account should be unpacked, but examples can help to convey the basic idea. Thick concepts are often illustrated with virtue concepts like courageous and generous, action concepts like murder and betray, epistemic concepts like dogmatic and wise, and aesthetic concepts like gaudy and brilliant. These concepts seem to be evaluative, unlike purely descriptive concepts (...) such as red and water. But they also seem different from general evaluative concepts. In particular, thick concepts are typically contrasted with thin concepts like good, wrong, permissible, and ought, which are general evaluative concepts that do not seem substantially descriptive. When Jane says that Max is good, she appears to be evaluating him without providing much description, if any. Thick concepts, on the other hand, are evaluative and substantially descriptive at the same time. For instance, when Max says that Jane is courageous, he seems to be doing two things: evaluating her positively and describing her as willing to face risk. Because of their descriptiveness, thick concepts are especially good candidates for evaluative concepts that pick out properties in the world. Thus they provide an avenue for thinking about ethical claims as being about the world in the same way as descriptive claims. -/- Thick concepts became a focal point in ethics during the second half of the twentieth century. At that time, discussions of thick concepts began to emerge in response to certain disagreements about thin concepts. For example, in twentieth-century ethics, consequentialists and deontologists hotly debated various accounts of good and right. It was also claimed by non-cognitivists and error-theorists that these thin concepts do not correspond to any properties in the world. Dissatisfaction with these viewpoints prompted many ethicists to consider the implications of thick concepts. The notion of a thick concept was thought to provide insight into meta-ethical questions such as whether there is a fact-value distinction, whether there are ethical truths, and, if there are such truths, whether these truths are objective. Some ethicists also theorized about the role that thick concepts can play in normative ethics, such as in virtue theory. By the beginning of the twenty-first century, the interest in thick concepts had spread to other philosophical disciplines such as epistemology, aesthetics, metaphysics, moral psychology, and the philosophy of law. -/- Nevertheless, the emerging interest in thick concepts has sparked debates over many questions: How exactly are thick concepts evaluative? How do they combine evaluation and description? How are thick concepts related to thin concepts? And do thick concepts have the sort of significance commonly attributed to them? This article surveys various attempts at answering these questions. (shrink)

In 1906, Henry Stephens Salt published a short collection of essays that presented several rhetorically powerful, if formally deficient arguments for the vegetarian position. By interpreting Salt as a moral sentimentalist with ties to Aristotelian virtue ethics, I propose that his aesthetic argument deserves contemporary consideration. First, I connect ethics and aesthetics with the Greek concepts of kalon and kalokagathia that depend equally on beauty and morality before presenting Salt’s assertion: slaughterhouses are disgusting, therefore they should not be promoted. I (...) suggest three areas of development since Salt’s death that could be fruitfully plumbed to rebuild this assertion into a contemporary argument: an updated analysis of factory farm conditions, insights from moral psychologists on the adaptive socio-biological benefits of disgust as a source of cognitive information, and hermeneutical considerations about the role of the audience that allow blameworthiness for slaughterhouse atrocities to be laid upon the meat-eater. (shrink)

Could a Nazi soldier or terrorist be courageous? The Courage Problem asks us to answer this sort of question, and then to explain why people are reluctant to give this answer. The present paper sheds new light on the Courage Problem by examining a controversy sparked by Bill Maher, who claimed that the 9/11 terrorists’ acts were ‘not cowardly.’ It is shown that Maher's controversy is fundamentally related to the Courage Problem. Then, a unified solution to both problems is provided. (...) This solution entails that gutsy people who lack good ends are not courageous. (shrink)

The paper argues, as against Thau and Caplan, that the traditional interpretation that Frege abandoned his earlier views about identity and identity--statements is correct.

Three separate churches erected in Constantinople were all dedicated to the wisdom of Christ and erected on the same site one after the other. These churches were built between 360 and 537 AD by three different emperors: Constantius II, Theodosius the Younger, and Justinian I. The first two churches were consumed in flames after relatively short lives, but the final and greatest church still stands today, despite a history of extensive damage. This final edifice is the main focus of this (...) paper, owing to its 1500 year longevity and unprecedented architecture. If the entire History of Justinian's church is to considered, it is inaccurate to refer to it as a “church,” because although it remained a church for the first 900 years after its audacious construction, it was later converted into a mosque. Today it is a museum, in remembrance of its long history. (24). (shrink)

I address questions about values in model-making in engineering, specifically: Might the role of values be attributable solely to interests involved in specifying and using the model? Selected examples illustrate the surprisingly wide variety of things one must take into account in the model-making itself. The notions of system, and physically similar systems are important and powerful in determining what is relevant to an engineering model. Another example illustrates how an idea to completely re-characterize, or reframe, an engineering problem arose (...) during model-making. I employ a qualitative analogue of the notion of physically similar systems. Historical cases can thus be drawn upon; I illustrate with a comparison between a geoengineering proposal to inject, or spray, sulfate aerosols, and two different historical cases involving the spraying of DDT. The current geoengineering proposal is seen to be like the disastrous and counterproductive case, and unlike the successful case, of the spraying of DDT. I conclude by explaining my view that model-making in science is analogous to moral perception in action, drawing on a view in moral theory that has come to be called moral particularism. (shrink)

A liberalism which scorns all individualism is fundamentally misguided. This is the chief thesis of this paper. To argue for it, I look closely at some key concepts. The concepts of morislity and individualism are crucial. I emphasize Dewey on the "individuality of the mind" and a Deweyan discussion of language, communication, and community. The thesis links individualism and liberalism, and since appeals to liberalism have broader appeal in the present context of discussions, I start with consideration of liberalism. The (...) aim is to dispute overly restrictive conceptions and explore a broader perspective. To bring the argument to a close, attention turns first to Dewey on value inquiry, to Dewey's "democratic individualism" (cf. Dewey 1939, 179), and to the concept of moral community. Disputing the acquisitiveness of utilitarian influences in classical liberalism, a Deweyan argument from the nature of moral community supports re-emphasis on individualism in contemporary liberal thought. (shrink)

For Albert Camus, plague was both a fact of life and a powerful metaphor for the human condition. Camus engaged most explicitly and extensively with the subject of plague in his 1947 novel, The Plague (La peste), which chronicles an outbreak of what is presumably cholera in the French-Algerian city of Oran. I often thought of this novel—and what it might teach us—during the recent COVID-19 pandemic. In this article, I discuss seven important insights from The Plague about epidemics, public (...) health and morality. (shrink)

2022 UPDATE: The approach of this paper has been updated and developed further in the author’s 2021 book _Critique of Impure Reason: Horizons of Possibility and Meaning_. The book is available both in a printed edition (under ISBN 978-0-578-88646-6 from Barnes & Noble, Amazon, and other booksellers) and an Open Access eBook edition (available through Philpapers under the book’s title and other philosophy online archives). ●●●●● The author distinguishes between the “information-oriented” approach of conservative, traditional philosophy, and an approach to (...) philosophy as “conceptual therapy.” The former emphasizes scholarship, textual explication and criticism, and, in general, a knowledge of the views of traditional thinkers. Philosophy as conceptual therapy, on the other hand, seeks an improvement of intellectual skills, and fosters a therapy for concepts and, by inference, a therapy for thinkers. The major concern of the paper is to argue that the traditional information-oriented approach to philosophy does not help its students effectively to develop intellectual skills, and that a conception of philosophy as conceptual therapy can provide a valuable contribution to the teaching and to the subject-matter of philosophy. (shrink)

Take the strong rhetoric! This expression comes to mind as we set in order the ideas and impressions prompted by Sandra Harding’s “An Organic Logic of Research: A Response to Posey and Navarro”.

Ever since John Locke, philosophers have discussed the possibility of a normative epistemology: are there epistemic obligations binding the cognitive economy of belief and disbelief? Locke's influential answer was evidentialist: we have an epistemic obligation to believe in accordance with our evidence. In this dissertation, I place the contemporary literature on agency and reasons at the service of some such normative epistemology. I discuss the semantics of obligations, the connection between obligations and reasons to believe, the implausibility of Lockean evidentialism, (...) and some of the alleged connections between agency and justification. (shrink)

Uno de los conceptos fundamentales del área de las Ciencias humanas y sociales es el de «cognición social». Este término se suele utilizar para referir teorías, categorías y principios que explican e interpretan fenómenos relacionados con el conocimiento que los seres humanos poseen sobre el mundo social.

Si celebramos hoy, 19 de noviembre, el Día Mundial de la Filosofía, es porque consideramos que la Filosofía es una especie de patrimonio de la humanidad ¿verdad? Pero ¿qué hay en la filosofía que la haga merecedora de este calificativo? Para indagar en algunas de las razones que justifican este nombramiento de la UNESCO (...).

As the collective impact of human activity approaches Earth’s biophysical limits, the ethics of food become increasingly important. Hundreds of millions of people remain undernourished, yet only 60 percent of the global harvest is consumed by humans, while 35 percent is fed to livestock and 5 percent is used for biofuels and other industrial products. This essay considers the ethics of such use of edible nutrition for feedstock and biofuel. How humanity uses Earth’s land is a reflection of its values. (...) The current land-use arrangements, which divert 40 percent of all food to feed animals or create fuels, suggest that dietary and transportation preferences of wealthier individuals are considered more important than feeding undernourished people, or the stability of the wider biotic community. (shrink)

A tongue-in-cheek marketing review of university philosophy prompted by a slow-down in sales and mounting criticism of the product. These problems are diagnosed as the consequence of an inward-looking culture that encourages a narrow and fixed focus on selling the traditional product while discouraging examination of its competitors.

Two fundamentally distinct approaches to the teaching of philosophy are contrasted: On the one hand, there is the “information-oriented” approach which has dominated classrooms and which emphasizes the understanding of historically important philosophical works. On the other hand, there is the “cognitive skills” approach. The two approaches may be distinguished under the headings of ‘knowing that’ as opposed to ‘knowing how’. This paper describes and discusses four perspectives relating to the teaching of cognitive skills: (i) the discovery-oriented approach, (ii) Piagetian (...) learning cycles, (iii) protocol analysis, and (iv) conceptual therapy. The latter approach reflects the author’s interest in helping students to develop “therapeutic” skills that enable them to identify and eliminate concepts which they employ in their thinking and which are incompatible with their own presuppositional bases and are therefore self-refuting. ●●●●● -/- 2022 UPDATE: The approach of this paper has been updated and developed further in Appendix II, "Epistemological Intelligence," of the author’s 2021 book _Critique of Impure Reason: Horizons of Possibility and Meaning_. The book is available both in a printed edition (under ISBN 978-0-578-88646-6 from Barnes & Noble, Amazon, and other booksellers) and an Open Access eBook edition (available through Philpapers under the book’s title and other philosophy online archives). (shrink)

Value Sensitive Design (VSD) is an established method for integrating values into technical design. It has been applied to different technologies and, more recently, to artificial intelligence (AI). We argue that AI poses a number of challenges specific to VSD that require a somewhat modified VSD approach. Machine learning (ML), in particular, poses two challenges. First, humans may not understand how an AI system learns certain things. This requires paying attention to values such as transparency, explicability, and accountability. Second, ML (...) may lead to AI systems adapting in ways that ‘disembody’ the values embedded in them. To address this, we propose a threefold modified VSD approach: 1) integrating a known set of VSD principles (AI4SG) as design norms from which more specific design requirements can be derived; 2) distinguishing between values that are promoted and respected by the design to ensure outcomes that not only do no harm but also contribute to good; and 3) extending the VSD process to encompass the whole life cycle of an AI technology in order to monitor unintended value consequences and redesign as needed. We illustrate our VSD for AI approach with an example use case of a SARS-CoV-2 contact tracing app. (shrink)